Wednesday

NFL Betting

St. Louis at San Francisco -9.5

O/U 37.5

ST. LOUIS (0-3) at SAN FRANCISCO (2-1)

Sunday 4 p.m., FOX

Line: San Francisco -9.5

Head-to-head: St. Louis, 60-56-2

Last season: San Francisco won both meetings, 35-16 and 17-16

Notable: 49ers RB Frank Gore ran for 106 yards and 2 TDs in the first game and missed the second. Rams RB Steven Jackson missed the first game and ran 32 times for 108 yards in the encore.

Last week: San Francisco lost 27-24 in Minnesota, St. Louis lost 36-17 to Green Bay.

Notable: 49ers TE Vernon Davis caught 7 passes for 96 yards and 2 TDs. Jackson ran for 117 yards and led the Rams in receiving with 5 catches for 46 yards.

How they stack up:

St. Louis offense: 32nd in points, 28th in total yards: 29th passing, 13th rushing

St. Louis defense: 26th in points, 29th in yards allowed: 25th against pass, 27th against run

San Francisco offense: 10th in points, 29th in total yards: 27th passing, 16th rushing

San Francisco defense: 10th in points, 13th in yards allowed: 24th against pass, 4th against run

Fantasy spin: Jackson will see a minimum of 8 Niners stacked against him every play. He might gain a lot of yards but it will take a lot of carries. With Gore out, 49ers rookie RB Glen Coffee has a promising home debut ahead.

Key injuries: Marc Bulger, Laurent Robinson, Frank Gore

The skinny: If the Rams protect the ball, this might be a trap game for the Niners, who are coming off the Favre finish. Expect San Francisco to win but the Rams could keep this one close. Take the points.